Sjögren's Systemic Clinical Activity Index (SCAI)—a systemic disease activity measure for use in clinical trials in primary Sjögren's syndrome
Identifieur interne : 001A61 ( Main/Exploration ); précédent : 001A60; suivant : 001A62Sjögren's Systemic Clinical Activity Index (SCAI)—a systemic disease activity measure for use in clinical trials in primary Sjögren's syndrome
Auteurs : S. J. Bowman [Royaume-Uni] ; N. Sutcliffe [Royaume-Uni] ; D. A. Isenberg [Royaume-Uni] ; F. Goldblatt [Royaume-Uni] ; M. Adler [Royaume-Uni] ; E. Price [Royaume-Uni] ; A. Canavan [Royaume-Uni] ; J. Hamburger [Royaume-Uni] ; A. Richards [Royaume-Uni] ; S. Rauz [Royaume-Uni] ; M. Regan [Royaume-Uni] ; K. Gadsby [Royaume-Uni] ; S. Rigby [Royaume-Uni] ; A. Jones [Royaume-Uni] ; R. Mathew [Royaume-Uni] ; D. Mulherin [Royaume-Uni] ; A. Stevenson [Royaume-Uni] ; P. Nightingale [Royaume-Uni]Source :
- Rheumatology [ 1462-0324 ] ; 2007.
Abstract
Objective. This article describes the development of the Sjögren's Systemic Clinical Activity Index (SCAI) for the measurement of systemic disease activity in patients with primary Sjögren's syndrome (PSS). Methods. A pilot tool was developed based on expert consensus and previous published data. One hundred and four patients with PSS were evaluated in a cross-sectional analysis, of whom 65 were reviewed at 3-monthly intervals, using this index, over a 12-month period. Factor analysis was used to evaluate the proposed domain structure. External validation was assessed by comparison with relevant domains of the Profile of Fatigue and Discomfort (PROFAD), Medical Outcomes Study Short Form-36 (SF-36) and The World Health Organization Quality of Life-Bref (WHOQOL-BREF). Sensitivity to change was assessed by comparing SCAI-derived flares with physician-designated disease flare and intention-to-treat analysis. A reliability and repeatability workshop was also held. Results. Factor analysis supported the proposed domain structure. There were strong correlations between the SCAI fatigue, musculoskeletal and Raynaud's components and the PROFAD fatigue, arthralgia and vascular domains. There was a significant correlation between change in therapy and SCAI-defined flares (P = 0.01). The mean κ-test results both for reliability of the SCAI and for physician repeatability were 0.71. Conclusion. This initial evaluation supports the potential for the SCAI as a tool for systemic activity assessment in patients with PSS but additional work is required to assess sensitivity to change in clinical therapeutic trials.
Url:
DOI: 10.1093/rheumatology/kem280
Affiliations:
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Adler</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Price, E" sort="Price, E" uniqKey="Price E" first="E." last="Price">E. Price</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Canavan, A" sort="Canavan, A" uniqKey="Canavan A" first="A." last="Canavan">A. Canavan</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Hamburger, J" sort="Hamburger, J" uniqKey="Hamburger J" first="J." last="Hamburger">J. Hamburger</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Richards, A" sort="Richards, A" uniqKey="Richards A" first="A." last="Richards">A. Richards</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Rauz, S" sort="Rauz, S" uniqKey="Rauz S" first="S." last="Rauz">S. Rauz</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Regan, M" sort="Regan, M" uniqKey="Regan M" first="M." last="Regan">M. Regan</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Gadsby, K" sort="Gadsby, K" uniqKey="Gadsby K" first="K." last="Gadsby">K. Gadsby</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Rigby, S" sort="Rigby, S" uniqKey="Rigby S" first="S." last="Rigby">S. Rigby</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Jones, A" sort="Jones, A" uniqKey="Jones A" first="A." last="Jones">A. Jones</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Mathew, R" sort="Mathew, R" uniqKey="Mathew R" first="R." last="Mathew">R. Mathew</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Mulherin, D" sort="Mulherin, D" uniqKey="Mulherin D" first="D." last="Mulherin">D. Mulherin</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Stevenson, A" sort="Stevenson, A" uniqKey="Stevenson A" first="A." last="Stevenson">A. Stevenson</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Nightingale, P" sort="Nightingale, P" uniqKey="Nightingale P" first="P." last="Nightingale">P. Nightingale</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, Barts & The Royal London Hospital, University College London, Great Western Hospital, Swindon, Birmingham Dental Hospital & School, Academic Unit of Ophthalmology, University of Birmingham, Derbyshire Royal Infirmary, Warwick Hospital, Nottingham University Hospitals, Cannock Chase Hospital and Wolfson Computer Laboratories, University of Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Rheumatology</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><publisher>Oxford University Press</publisher><date when="2007-12">2007</date><biblScope unit="vol">46</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1845">1845</biblScope><biblScope unit="page" to="1851">1851</biblScope></imprint><idno type="ISSN">1462-0324</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objective. This article describes the development of the Sjögren's Systemic Clinical Activity Index (SCAI) for the measurement of systemic disease activity in patients with primary Sjögren's syndrome (PSS). Methods. A pilot tool was developed based on expert consensus and previous published data. One hundred and four patients with PSS were evaluated in a cross-sectional analysis, of whom 65 were reviewed at 3-monthly intervals, using this index, over a 12-month period. Factor analysis was used to evaluate the proposed domain structure. External validation was assessed by comparison with relevant domains of the Profile of Fatigue and Discomfort (PROFAD), Medical Outcomes Study Short Form-36 (SF-36) and The World Health Organization Quality of Life-Bref (WHOQOL-BREF). Sensitivity to change was assessed by comparing SCAI-derived flares with physician-designated disease flare and intention-to-treat analysis. A reliability and repeatability workshop was also held. Results. Factor analysis supported the proposed domain structure. There were strong correlations between the SCAI fatigue, musculoskeletal and Raynaud's components and the PROFAD fatigue, arthralgia and vascular domains. There was a significant correlation between change in therapy and SCAI-defined flares (P = 0.01). The mean κ-test results both for reliability of the SCAI and for physician repeatability were 0.71. Conclusion. This initial evaluation supports the potential for the SCAI as a tool for systemic activity assessment in patients with PSS but additional work is required to assess sensitivity to change in clinical therapeutic trials.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li></settlement><orgName><li>Université de Birmingham</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bowman, S J" sort="Bowman, S J" uniqKey="Bowman S" first="S. J." last="Bowman">S. J. Bowman</name></region><name sortKey="Adler, M" sort="Adler, M" uniqKey="Adler M" first="M." last="Adler">M. Adler</name><name sortKey="Bowman, S J" sort="Bowman, S J" uniqKey="Bowman S" first="S. J." last="Bowman">S. J. Bowman</name><name sortKey="Canavan, A" sort="Canavan, A" uniqKey="Canavan A" first="A." last="Canavan">A. Canavan</name><name sortKey="Gadsby, K" sort="Gadsby, K" uniqKey="Gadsby K" first="K." last="Gadsby">K. Gadsby</name><name sortKey="Goldblatt, F" sort="Goldblatt, F" uniqKey="Goldblatt F" first="F." last="Goldblatt">F. Goldblatt</name><name sortKey="Hamburger, J" sort="Hamburger, J" uniqKey="Hamburger J" first="J." last="Hamburger">J. Hamburger</name><name sortKey="Isenberg, D A" sort="Isenberg, D A" uniqKey="Isenberg D" first="D. A." last="Isenberg">D. A. Isenberg</name><name sortKey="Jones, A" sort="Jones, A" uniqKey="Jones A" first="A." last="Jones">A. Jones</name><name sortKey="Mathew, R" sort="Mathew, R" uniqKey="Mathew R" first="R." last="Mathew">R. Mathew</name><name sortKey="Mulherin, D" sort="Mulherin, D" uniqKey="Mulherin D" first="D." last="Mulherin">D. Mulherin</name><name sortKey="Nightingale, P" sort="Nightingale, P" uniqKey="Nightingale P" first="P." last="Nightingale">P. Nightingale</name><name sortKey="Price, E" sort="Price, E" uniqKey="Price E" first="E." last="Price">E. Price</name><name sortKey="Rauz, S" sort="Rauz, S" uniqKey="Rauz S" first="S." last="Rauz">S. Rauz</name><name sortKey="Regan, M" sort="Regan, M" uniqKey="Regan M" first="M." last="Regan">M. Regan</name><name sortKey="Richards, A" sort="Richards, A" uniqKey="Richards A" first="A." last="Richards">A. Richards</name><name sortKey="Rigby, S" sort="Rigby, S" uniqKey="Rigby S" first="S." last="Rigby">S. Rigby</name><name sortKey="Stevenson, A" sort="Stevenson, A" uniqKey="Stevenson A" first="A." last="Stevenson">A. Stevenson</name><name sortKey="Sutcliffe, N" sort="Sutcliffe, N" uniqKey="Sutcliffe N" first="N." last="Sutcliffe">N. Sutcliffe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Sjögren's Systemic Clinical Activity Index (SCAI)—a systemic disease activity measure for use in clinical trials in primary Sjögren's syndrome
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